Host Metabolism and Responses Contributing to Flavivirus Replication and Pathogenesis

Grant number: 1081786 | Funding period: 2015 - 2017

Completed

Abstract

We aim to determine how viruses affect the cells they infect, In particular how they can alter the metabolism and balance of lipids in cells and how this impacts the bodies capability to respond immunologically. We believe that by understanding these basic principles we can target ares fr antiviral therapeutic potential.

Related publications (4)

Adenovirus vector produced Zika virus-like particles induce a long-lived neutralising antibody response in mice

J Carrera, TE Aktepe, L Earnest, D Christiansen, AK Wheatley, HX Tan, AW Chung, S Collett, K McPherson, J Torresi, JM Mackenzie, CP Simmons

2023-07-25

Countermeasures against Zika virus (ZIKV) epidemics are urgently needed. In this study we generated a ZIKV virus-like particle (VL..

Flavivirus replication kinetics in early-term placental cell lines with different differentiation pathways

J Carrera, AM Trenerry, CP Simmons, JM Mackenzie

2021-12-01

Background: The uncontrollable spread of Zika virus (ZIKV) in the Americas during 2015–2017, and its causal link to microcephaly i..

Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus

S Liebscher, RL Ambrose, TE Aktepe, A Mikulasova, JE Prier, LK Gillespie, AJ Lopez-Denman, TWT Rupasinghe, D Tull, MJ McConville, JM Mackenzie

2018-04-30

Positive-sense RNA virus intracellular replication is intimately associated with membrane platforms that are derived from host org..

The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling

TE Aktepe, S Liebscher, JE Prier, CP Simmons, JM Mackenzie

2017-11-07

Flaviviruses are enveloped, positive-sensed single-stranded RNA viruses that remodel host membranes, incorporating both viral and ..

University of Melbourne Researchers

Jason Mackenzie